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RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Gene Name: | RAD17 homolog (S. pombe) |
Synonyms: | RAD17, HRAD17, R24L, RAD1 homolog, RAD1 (S. pombe) homolog, RAD24, Rad17-like protein, RF-C activator 1 homolog, CCYC, RAD17 homolog (S. pombe), RAD17SP, RF-C/activator 1 homolog |
Target Sequences: | NM_002873 NP_002864.1 O75943 |
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