RAB7A / RAB7

RAB7A, member RAS oncogene family

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

RAB7A / RAB7 (6)

Publications

No (6)

Tag

GST (1)

His (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human RAB7A / RAB7 Protein (Recombinant His) - LS-G1099

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human RAB7A / RAB7 Protein (Recombinant GST) (Full Length) - LS-G31023

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RAB7A / RAB7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$1,107

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Human RAB7A / RAB7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88634

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$150

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RAB7A / RAB7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116514

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

100 µg/$494

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Rat RAB7A / RAB7 Protein (Recombinant His) (Met1-Cys207) - LS-G98469

Source:

E. coli

Tag:

His

Molecular Weight:

25.7 kDa

Price:

100 µg/$600

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