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Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Gene Name: | queuine tRNA-ribosyltransferase 1 |
Synonyms: | QTRT1, FP3235, Guanine insertion enzyme, TGT, catalytic subunit, TGUT, TGT, 43-KD subunit, TGT, TRNA-guanine transglycosylase |
Target Sequences: | NM_031209 NP_112486.1 Q9BXR0 |
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