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QPRT

quinolinate phosphoribosyltransferase

QPRT is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Gene Name: quinolinate phosphoribosyltransferase
Synonyms: QPRT, QPRTase, QAPRTase
Target Sequences: NM_014298 NP_055113.2 Q15274

Publications (2)

1
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. Jones SP, Franco NF, Varney B, Sundaram G, Brown DA, de Bie J, Lim CK, Guillemin GJ, Brew BJ. PloS one. 2015 10:e0131389. (WB; Human) [Full Text Article] [PubMed:26114426] [PMC:PMC4482723] Related Antibodies: LS-C115527.
2
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. Yinghong Zheng, Jiayuan Kou, Pengyu Wang, Ting Ye, Zitong Wang, Ziyu Gao, Lin Cong, Manman Li, Bowen Dong, Wei Yang, Quanfeng Li, Hong Li, Rui Wang, Liming Yang. Aging. 2021 Feb;13:7096-7119. [Full Text Article] [PubMed:33639613] [PMC:PMC7993719]

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
QPRT (8)
No (8)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
QPRT Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
QPRT Protein - 12.5% SDS-PAGE of human QPRT stained with Coomassie Blue
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Wheat Germ Extract
GST
58.3 kDa
10 µg/$479; 25 µg/$670
QPRT Protein - Purified recombinant protein QPRT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$1,107
QPRT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
QPRT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
QPRT Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.0 kDa
10 µg/$344; 50 µg/$584
Viewing 1-8 of 8 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).