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PTPRN / IA-2

protein tyrosine phosphatase, receptor type, N

PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene Name: protein tyrosine phosphatase, receptor type, N
Family/Subfamily: Protein Phosphatase , R8
Synonyms: PTPRN, ICA512, IA2, ICA 512, Islet antigen 2, Islet cell antigen 2, Islet cell autoantigen 3, IA-2, Ia-2 antigen, ICA3, PTP-NP-2, PTP IA-2, R-PTP-N, IA-2/PTP, Islet cell antigen 512
Target Sequences: NM_002846 NP_002837.1 Q16849

Publications (1)

1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster) [Full Text Article] [PubMed:28694505] [PMC:PMC5504025] Related Antibodies: LS-C284886.

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Antibodies (39)
Primary (39)
PTPRN / IA-2 (39)
Human (39)
Mouse (6)
Rat (22)
Bovine (3)
Guinea pig (3)
Monkey (3)
Orangutan (3)
Pig (3)
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rabbit (37)
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monoclonal mc (2)
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APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (14)
aa35-185 (8)
aa368-575 (8)
aa288-316 (7)
aa32-81 (4)
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PTPRN / IA-2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 0.0625 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa32-81) Antibody
Human
WB
Unconjugated
100 µl/$424
PTPRN / IA-2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 0.0625 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa32-81) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Orangutan, Human, Monkey
WB
HRP Conjugated
100 µl/$469
PTPRN / IA-2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 0.0625 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa32-81) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Orangutan, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PTPRN / IA-2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 0.0625 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa32-81) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Orangutan, Human, Monkey
WB
FITC Conjugated
100 µl/$469
PTPRN / IA-2 Antibody - Anti-PTPRN antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTPRN / IA-2 Mouse anti-Human Monoclonal (8E3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
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PTPRN / IA-2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$371
PTPRN / IA-2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa368-575) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
PTPRN / IA-2 Antibody - Western blot analysis of extracts of mouse stomach cells.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PTPRN / IA-2 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using PTPRN Polyclonal Antibody at dilution of 1:55(×200)
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
PTPRN / IA-2 Antibody - Immunochemical staining of human PTPRN in human pancreas with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$412
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PTPRN / IA-2 Antibody - PTPRN Antibody western blot of Jurkat cell line lysates (35 ug/lane). The PTPRN antibody detected the PTPRN protein (arrow).
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) Antibody
Human
WB
Unconjugated
400 µl/$393
PTPRN / IA-2 Antibody
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PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
PTPRN / IA-2 Antibody - Western blot of PTPRN / IA-2 antibody.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa35-185) Antibody
Rat, Human
WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).