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PTPN5 / STEP
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
Striatum-enriched phosphatase, a R7 receptor protein tyrosine phosphatase, is a component of the NMDAR complex and has been suggested affect the development and maturation of the striatal neurons. STEP has been shown to regulate the activity of Fyn and may be one mechanism by which Fyn activity is decreased within the postsynaptic densities (PSDs) of striatal neurons. Alternative splicing of STEP produces cytosolic, transmembrane, and truncated isoforms. Three alternatively spliced isoforms have been isolated: Step46 - a cytosolic form, Step61 - a membrane form containing 172 additional amino acids in the N terminus when compared to Step46, and Step20 which lacks the tyrosine phosphatase domain.
| Gene Name: | protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) |
| Family/Subfamily: | Protein Phosphatase , R7 receptor |
| Synonyms: | PTPN5, Striatal enriched phosphatase, Striatum enriched phosphatase, PTPSTEP, STEP |
| Target Sequences: | NM_006906 AAA87555.1 P54829 |
Publications (20)
1
Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. Boulanger LM, Lombroso PJ, Raghunathan A, During MJ, Wahle P, Naegele JR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1995 15:1532-44.
[PubMed:7869116]
2
STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 16:7821-31. (WB, IHC-Fr)
[PubMed:8987810]
3
Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP). Gurd JW, Bissoon N, Nguyen TH, Lombroso PJ, Rider CC, Beesley PW, Vannucci SJ. Journal of neurochemistry. 1999 73:1990-4.
[PubMed:10537057]
☰ Filters
Products
Antibodies
(47)
Proteins
(15)
Type
Over-Expression Lysate
(8)
Primary
(47)
Recombinant
(7)
Target
PTPN5 / STEP
(62)
Reactivity
Human
(33)
Mouse
(18)
Rat
(18)
Bat
(3)
Bovine
(3)
Chicken
(3)
Chimpanzee
(3)
Dog
(3)
Gibbon
(3)
Guinea pig
(3)
Horse
(3)
Monkey
(3)
Orangutan
(3)
Pig
(3)
Rabbit
(3)
Xenopus
(3)
Zebrafish
(3)
Application
IHC
(18)
IHC-P
(6)
WB
(43)
ELISA
(18)
IF
(1)
IP
(6)
Host
rabbit
(40)
mouse
(7)
Product Group
IHCPlus
(1)
Isotype
IgG
(23)
IgG1
(2)
Clonality
monoclonal mc
(7)
polyclonal pc
(40)
Clone
23E5
(1)
Format
APC
(2)
APC Conjugated
(5)
Azide-free
(2)
Biotin Conjugated
(7)
Cy3 Conjugated
(2)
Cy7 Conjugated
(2)
FITC Conjugated
(7)
HRP Conjugated
(7)
PE Conjugated
(5)
Unconjugated
(12)
Epitope
aa1-30
(7)
aa168-198
(7)
aa179-228
(4)
aa300-555
(4)
N-Terminus
(1)
aa57-74
(1)
Publications
No
(62)
Tag
GST
(1)
GST, N-terminus
(1)
His-SUMO
(1)
His-T7, N-terminus
(2)
Myc-DDK (Flag)
(10)
Species
Human
(10)
Mouse
(1)
Source
293T Cells
(4)
E. coli
(3)
HEK 293 Cells
(6)
Wheat Germ Extract
(2)
Purification
Purified
(2)
E. coli
His-SUMO
45.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PTPN5 / STEP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa179-228) Antibody
Human
WB
Unconjugated
100 µl/$424
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa300-555) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa300-555) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa300-555) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa300-555) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa168-198) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
PTPN5 / STEP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
PTPN5 / STEP Mouse anti-Rat Monoclonal (aa57-74) (23E5) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
0.1 ml/$386
PTPN5 / STEP Mouse anti-Rat Monoclonal (HRP) Antibody
Mouse, Rat
IHC, IP, WB
HRP Conjugated
100 µl/$1,085
PTPN5 / STEP Mouse anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat
IHC, IP, WB
Biotin Conjugated
100 µl/$1,085
PTPN5 / STEP Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat
IHC, IP, WB
FITC Conjugated
100 µl/$1,085
PTPN5 / STEP Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat
IHC, IP, WB
APC Conjugated
100 µl/$1,085
PTPN5 / STEP Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Rat
IHC, IP, WB
PE Conjugated
100 µl/$1,085
Viewing 1-25
of 62
product results
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