Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.
Gene Name: | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
Family/Subfamily: | Protein Phosphatase , NT4 |
Synonyms: | PTPN22, 70zpep, Lymphoid phosphatase, LYP, PEST-domain phosphatase, LYP2, LYP1, PEP, PTPN8 |
Target Sequences: | NM_015967 NP_057051.3 Q9Y2R2 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.