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PTPN18

protein tyrosine phosphatase, non-receptor type 18 (brain-derived)

PTPN18 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Family/Subfamily: Protein Phosphatase , NT4
Synonyms: PTPN18, Brain-derived phosphatase, PTP-HSCF, Ptp-k1, PTP20
Target Sequences: NM_014369 NP_055184.2 Q99952

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
PTPN18 (6)
No (6)
GST (1)
Myc-DDK (Flag) (5)
Human (4)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
PTPN18 Protein - 12.5% SDS-PAGE of human PTPN18 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.7 kDa
2 µg/$439
PTPN18 Protein - Purified recombinant protein PTPN18 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50.3 kDa
20 µg/$1,107
PTPN18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
50.3 kDa
20 µg/$215
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HEK 293 Cells
Myc-DDK (Flag)
50.3 kDa
100 µg/$710
PTPN18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).