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PTPN18 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) |
Family/Subfamily: | Protein Phosphatase , NT4 |
Synonyms: | PTPN18, Brain-derived phosphatase, PTP-HSCF, Ptp-k1, PTP20 |
Target Sequences: | NM_014369 NP_055184.2 Q99952 |
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