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PTP4A2 / PRL-2 belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
Gene Name: | protein tyrosine phosphatase type IVA, member 2 |
Family/Subfamily: | Protein Phosphatase , PTP4A |
Synonyms: | PTP4A2, HH7-2, HH13, HU-PP-1, PRL-2, PRL2, Ptp-IV1a, PTPCAAX2, PTP(CAAXII), Ptp-IV1b, OV-1, PTP4A |
Target Sequences: | NM_080391 AAH70182.1 Q12974 |
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