PTP1B

protein tyrosine phosphatase, non-receptor type 1

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (11)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (7)

Target

PTP1B (11)

Publications

No (11)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (10)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (4)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Biologically Active

Biologically active (1)

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Human PTP1B Protein (Recombinant) - LS-G3534

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human PTP1B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66734

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

20 µg/$1,107

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Human PTP1B Protein (Recombinant GST, N-terminus) (aa322-406) - LS-G59819

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PTP1B Protein (Over-Expression Lysate 6His, N-terminus) (Glu2-Thr431) - LS-G26731

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

25 kDa

Price:

100 µg/$298

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Human PTP1B Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Glu2-Thr431) - LS-G26868

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

25 kDa

Price:

200 µl/$283

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Human PTP1B Protein (Recombinant GST) (Full Length) - LS-G30033

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PTP1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78395

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

20 µg/$150

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PTP1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117743

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

100 µg/$494

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Human PTP1B Protein (Recombinant His, N-Terminal) - LS-G143833

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

39.2 KDa

Price:

100 µg/$677

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Human PTP1B Protein (Recombinant DDK,C-terminus) - LS-G142420

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

49.8 kDa

Price:

20 µg/$677

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Human PTP1B Protein (Recombinant His) (Glu2-Asn321) - LS-G97812

Source:

E. coli

Tag:

His

Molecular Weight:

38 kDa

Price:

100 µg/$948

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