PTP1B

protein tyrosine phosphatase, non-receptor type 1

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

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Products

ELISA Kits (12)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (4)

Sandwich (6)

Target

PTP1B (12)

Reactivity

Human (7)

Mouse (4)

Rat (4)

Chicken (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (8)

Publications

No (12)

Sample Type

Adherent Cell Cultures (2)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

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Mouse PTP1B (Sandwich ELISA) ELISA Kit - LS-F17120

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human PTP1B (Sandwich ELISA) ELISA Kit - LS-F24020

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse/Human/Rat PTP1B (Cell-Based ELISA) ELISA Kit - LS-F2275

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-PTP1B (Ser50) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1309

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human PTP1B (Sandwich ELISA) ELISA Kit - LS-F9082

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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Chicken PTP1B (Custom ELISA) ELISA Kit - LS-F17121

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human PTP1B (Custom ELISA) ELISA Kit - LS-F17122

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Rat PTP1B (Custom ELISA) ELISA Kit - LS-F17123

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Rat PTP1B (Sandwich ELISA) ELISA Kit - LS-F35683

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse PTP1B (Sandwich ELISA) ELISA Kit - LS-F35684

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PTP1B (Sandwich ELISA) ELISA Kit - LS-F36297

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PTP1B (Custom ELISA) ELISA Kit - LS-F50526

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$610

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