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PTHLH / PTHRP
parathyroid hormone-like hormone
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
| Gene Name: | parathyroid hormone-like hormone |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | PTHLH, Osteostatin, PTHR, PTH-related protein, PTHRP, BDE2, HHM, PLP, PTH-rP |
| Target Sequences: | NM_002820 NP_002811.1 P12272 |
Publications (6)
1
Bone adaptation in response to treadmill exercise in young and adult mice. Gardinier JD, Rostami N, Juliano L, Zhang C. Bone reports. 2018 January;8:29-37. [Full Text Article]
[PubMed:29379848]
[PMC:PMC5787623]
Related Antibodies: LS-B6787.
2
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. Sawsan Elattar, Manali Dimri, Ande Satyanarayana. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 September;32:4727-4743. [Full Text Article]
[PubMed:29570397]
[PMC:PMC6266632]
3
Expression of Signaling Molecules Involved in Embryonic Development of the Insertion Site Is Inadequate for Reformation of the Native Enthesis: Evaluation in a Novel Murine ACL Reconstruction Model. Xiang-Hua Deng, Amir Lebaschi, Christopher L Camp, Camila B Carballo, Nathan W Coleman, Jianchun Zong, Brian M Grawe, Scott A Rodeo. The Journal of bone and joint surgery. American volume. 2018 August;100:e102. [Full Text Article]
[PubMed:30063598]
[PMC:PMC6661256]
Related Antibodies: LS-B12325.
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PTHLH / PTHRP Rabbit anti-Mouse Polyclonal (aa77-126) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTHLH / PTHRP Rabbit anti-Mouse Polyclonal (aa77-126) (HRP) Antibody
Rabbit, Mouse, Goat, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PTHLH / PTHRP Rabbit anti-Human Polyclonal (aa25-175) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PTHLH / PTHRP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
PTHLH / PTHRP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
E. coli
His, N-Terminal
17.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$851
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PTHLH / PTHRP Mouse anti-Human Monoclonal (aa37-175) (677939) Antibody
Human
IHC
Unconjugated
100 µg/$884
PTHLH / PTHRP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
PTHLH / PTHRP Goat anti-Human Polyclonal (aa53-86) Antibody
Mouse, Dog, Rat, Pig, Bat, Human
RIA
Unconjugated
20 µl/$460; 100 µl/$809
PTHLH / PTHRP Rabbit anti-Chicken Polyclonal (aa38-176) Antibody
Chicken
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
PTHLH / PTHRP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
Sandwich
96-Well Strip Plate
Dog
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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