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PTGS2 / COX2 / COX-2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Gene Name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms: PTGS2, COX-2, Cyclooxygenase-2, COX2, Cyclooxygenase 2b, HCox-2, GRIPGHS, PGH synthase 2, PGHS-2, PHS II, PHS-2, Prostaglandin H2 synthase 2, PGG/HS, Prostaglandin G/H synthase 2
Target Sequences: NM_000963 NP_000954.1 P35354

Publications (7)

1
Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. The Journal of biological chemistry. 1998 273:28670-6. [PubMed:9786861] Related Antibodies: LS-B410.
2
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Tong M, Tai HH. Biochemical and biophysical research communications. 2000 276:77-81. [PubMed:11006085] Related Antibodies: LS-B410.
3
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Nature communications. 2018 April;9:1479. [Full Text Article] [PubMed:29662056] [PMC:PMC5902554]
4
Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. Zhang MZ, Wang S, Wang Y, Zhang Y, Ming Hao C, Harris RC. Hypertension. 2018 November;72:1172-1179. [Full Text Article] [PubMed:30354807] [PMC:PMC6207229] Related Antibodies: LS-C210609.
5
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Ju Youn Lee , Seung Hoon Han , Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Bae. Nature communications. 2020 May;11:2358. [Full Text Article] [PubMed:32398649] [PMC:PMC7217877]
6
Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation. Julia J Müller, Matthias Schwab, Charles R Rosenfeld, Iwa Antonow-Schlorke, Peter W Nathanielsz, Florian Rakers, Harald Schubert, Otto W Witte, Sven Rupprecht. Journal of vascular Research. 2017 August;54:259-271. [Full Text Article] [PubMed:28810262]
7
Extracellular vesicles in luminal fluid of the ovine uterus. Burns G, Brooks K, Wildung M, Navakanitworakul R, Christenson LK, Spencer TE. PloS one. 2014 9:e90913. [Full Text Article] [PubMed:24614226] [PMC:PMC3948691] Related Antibodies: LS-C150711.
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PTGS2 / COX2 / COX-2 (28)
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PTGS2 / COX2 / COX-2 ELISA Kit
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96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
PTGS2 / COX2 / COX-2 ELISA Kit
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96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 U/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Microplate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PTGS2 / COX2 / COX-2 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.2 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
PTGS2 / COX2 / COX-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PTGS2 / COX2 / COX-2 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).