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The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity.
Gene Name: | phosphatase and tensin homolog pseudogene 1 (functional) |
Family/Subfamily: | Protein Phosphatase , PTEN |
Synonyms: | PTENP1, PsiPTEN, MMAC1, PTEN-rs, PTEN2 |
Target Sequences: | AF019083 O43460 |
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