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PTCH2 / Patched 2
patched 2
PTCH2 / Patched 2 is a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.
| Gene Name: | patched 2 |
| Synonyms: | PTCH2, Patched (Drosophila) homolog 2, Patched 2, Patched homolog 2, Patched homolog 2 (Drosophila), Protein patched homolog 2, PTC2 |
| Target Sequences: | NM_003738 NP_003729.3 Q9Y6C5 |
Publications (3)
1
Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial. O'Hara WA, Azar WJ, Behringer RR, Renfree MB, Pask AJ. BMC developmental biology. 2011 11:72. (IHC; Marsupial)
[Full Text Article]
[PubMed:22132805]
[PMC:PMC3293750]
2
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL, Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J, Dierks C. The Journal of experimental medicine. 2016 213:273-90. (WB, ELISA; Human)
[Full Text Article]
[PubMed:26834157]
[PMC:PMC4749921]
3
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja. Cell reports. 2019 December;29:4553-4567.e7. [Full Text Article]
[PubMed:31875560]
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Antibodies
(16)
Type
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(16)
Target
PTCH2 / Patched 2
(16)
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Human
(15)
Mouse
(1)
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(4)
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(3)
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(1)
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(7)
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(5)
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(12)
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(2)
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(1)
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(1)
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rabbit
(12)
mouse
(4)
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IHCPlus
(1)
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IgG
(10)
IgG1
(4)
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monoclonal mc
(4)
polyclonal pc
(12)
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OTI1F5
(2)
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(2)
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(2)
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(2)
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(2)
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(2)
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(10)
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aa362-411
(4)
aa79-392
(4)
C-Terminus
(1)
aa885-901
(1)
Publications
No
(16)
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (aa885-901) Antibody
Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (aa362-411) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (aa362-411) (HRP) Antibody
Rabbit, Dog, Bovine, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (aa362-411) (Biotin) Antibody
Rabbit, Dog, Bovine, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (aa362-411) (FITC) Antibody
Rabbit, Dog, Bovine, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
PTCH2 / Patched 2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
PTCH2 / Patched 2 Rabbit anti-Yeast Polyclonal (C-Terminus) Antibody
Yeast
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
PTCH2 / Patched 2 Mouse anti-Human Monoclonal (aa79-392) (OTI8B5) Antibody
Human
WB
Unconjugated
100 µl/$434
PTCH2 / Patched 2 Mouse anti-Human Monoclonal (aa79-392) (Carrier-free) (OTI8B5) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
PTCH2 / Patched 2 Mouse anti-Human Monoclonal (aa79-392) (OTI1F5) Antibody
Human
WB
Unconjugated
100 µl/$434
PTCH2 / Patched 2 Mouse anti-Human Monoclonal (aa79-392) (Carrier-free) (OTI1F5) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
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