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PTAR2 / FNTA
farnesyltransferase, CAAX box, alpha
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
| Gene Name: | farnesyltransferase, CAAX box, alpha |
| Synonyms: | FNTA, FPTA, FTase-alpha, GGTase-I-alpha, PTAR2, PGGT1A |
| Target Sequences: | NM_002027 NP_002018.1 P49354 |
Publications (1)
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