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Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Gene Name: | proline/serine-rich coiled-coil 1 |
Synonyms: | PSRC1, DDA3, FP3214, p53-regulated DDA3 |
Target Sequences: | NM_032636 NP_116025.1 Q6PGN9 |
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