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Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
Gene Name: | phospholipase A1 member A |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLA1A, NMD, Phospholipase a1, PS-PLA1, Phospholipase A1 member A, PSPLA1 |
Target Sequences: | NM_015900 NP_056984.1 Q53H76 |
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