Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.
Gene Name: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
Family/Subfamily: | Protease Non Catalytic , not assigned-Protease Non Catalytic |
Synonyms: | PSMD11, 26s proteasome subunit 9, S9, Rpn6, p44.5 |
Target Sequences: | NM_002815 NP_002806.2 O00231 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.