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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 3 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMB3, HC10-II, Macropain theta chain, Proteasome chain 13, Proteasome theta chain, Proteasome subunit beta type-3, C10-ii, Proteasome component C10-II |
Target Sequences: | NM_002795 NP_002786.2 P49720 |
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