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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 2 |
Family/Subfamily: | Protease , Threonine T1 |
Synonyms: | PSMB2, Macropain subunit C7-I, HC7-I, Proteasome component C7-I, Proteasome beta 2 subunit, Proteasome subunit beta type-2, C7-I, Proteasome subunit beta 2 |
Target Sequences: | NM_002794 NP_002785.1 P49721 |
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