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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 10 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMB10, Beta2i, Low molecular mass protein 10, MECL1, Proteasome component mecl-1, Proteasome subunit beta-2i, Proteasome subunit beta 7i, Macropain subunit MECl-1, Proteasome MECl-1, LMP10, Proteasome subunit MECL1 |
Target Sequences: | BC017198 NP_002792.1 P40306 |
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