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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 1 |
Family/Subfamily: | Protease , Threonine T1 |
Synonyms: | PSMB1, Macropain subunit C5, HC5, PMSB1, Proteasome gamma chain, Proteasome subunit beta 1, Proteasome beta 1 subunit, Proteasome component C5, Lmpc5, Proteasome subunit beta type-1, Proteasome subunit HC5, PSC5 |
Target Sequences: | NM_002793 NP_002784.1 P20618 |
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