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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.
Gene Name: | proteasome (prosome, macropain) subunit, alpha type, 6 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMA6, 27 kDa prosomal protein, Macropain iota chain, PROS27, Proteasome iota chain, p27K, PROS-27, IOTA, Macropain subunit iota, Prosomal P27K protein, Proteasome subunit iota |
Target Sequences: | BC002979 AAH02979.1 P60900 |
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