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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Gene Name: | proteasome (prosome, macropain) subunit, alpha type, 5 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMA5, Proteasome component 5, Proteasome subunit zeta, Proteasome alpha 5 subunit, Macropain zeta chain, Zeta, Proteasome zeta chain, Macropain subunit zeta, Proteasome alpha-type 5, PSC5 |
Target Sequences: | NM_002790 NP_002781.2 P28066 |
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