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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Gene Name: | proteasome (prosome, macropain) subunit, alpha type, 3 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMA3, Proteasome component C8, Proteasome subunit C8, PSC8, HC8, Macropain subunit C8, PSC3 |
Target Sequences: | NM_002788 NP_002779.1 P25788 |
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