Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | proteasome (prosome, macropain) subunit, alpha type, 1 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMA1, 30 kDa prosomal protein, HC2, Macropain subunit C2, NU, PSC2, PROS30, Proteasome nu chain, Proteasome subunit alpha 1, Proteasome subunit nu, Protein P30-33K, Macropain subunit nu, PROS-30, Proteasome component C2 |
Target Sequences: | NM_002786 NP_002777.1 P25786 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.