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Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Gene Name: | PC4 and SFRS1 interacting protein 1 |
Synonyms: | PSIP1, DFS 70, DFS70, p52, p75, LEDGF, PSIP2, CLL-associated antigen KW-7, PAIP |
Target Sequences: | NM_033222 NP_150091.2 O75475 |
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