PSEN2 / Presenilin 2

presenilin 2 (Alzheimer disease 4)

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

☰ Filters

Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PSEN2 / Presenilin 2 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Select

PSEN2 / Presenilin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114395

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

100 µg/$494

Select

Human PSEN2 / Presenilin 2 Protein (Recombinant GST, N-terminus) (aa1-86) - LS-G59780

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PSEN2 / Presenilin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78169

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

20 µg/$150

Viewing 1-3 of 3 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.