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PRSS1 / Trypsin is a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
Gene Name: | protease, serine, 1 (trypsin 1) |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | PRSS1, Beta-trypsin, Cationic trypsinogen, Digestive zymogen, HPC, Hereditary pancreatitis, TRP1, TRY4, Trypsin, Trypsinogen i, TRYP1, Trypsinogen, TRY1, Trypsinogen 1, Nonfunctional trypsin 1, Protease serine 1, Serine protease 1, Trypsin I, Trypsin-1, Trypsinogen A |
Target Sequences: | NM_002769 NP_002760.1 P07477 |
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