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This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon.
Gene Name: | phosphoribosyl pyrophosphate synthetase 1-like 1 |
Synonyms: | PRPS1L1, PRPS1-like 1, PRPS3, PRPSL, PRS-III |
Target Sequences: | M57423 AAB59463.1 P21108 |
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