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Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Gene Name: | prostaglandin D2 synthase 21kDa (brain) |
Synonyms: | PTGDS, Beta-trace protein, LPGDS, PGD2, PGD2 synthase, PGDS, Prostaglandin D synthase, Prostaglandin-D2 synthase, L-PGDS, PDS, Cerebrin-28, PGDS2, Prostaglandin-H2 D-isomerase |
Target Sequences: | NM_000954 NP_000945.3 P41222 |
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