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Proenkephalin / PENK
proenkephalin
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
| Gene Name: | proenkephalin |
| Family/Subfamily: | Endogenous opioids , not assigned-Endogenous opioids |
| Synonyms: | PENK, Enkephalin A, Met enkephalin, Preproenkephalin, Proenkephalin, Proenkephalin-A |
| Target Sequences: | NM_006211 NP_006202.1 P01210 |
Publications (6)
1
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics. Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J. PLoS biology. 2018 June;16:e2006387. (Rat)
[Full Text Article]
[PubMed:29912866]
[PMC:PMC6029811]
2
Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. Krajeski RN, Macey-Dare A, van Heusden F, Ebrahimjee F, Ellender TJ. The Journal of physiology. 2019 November;597:5265-5293. [Full Text Article]
[PubMed:31531863]
[PMC:PMC6900874]
3
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Anna Piotrowska, Joanna Starnowska-Sokól, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewlocka. Pain. 2021 February;162:432-445. [Full Text Article]
[PubMed:32826750]
[PMC:PMC7808367]
Related Antibodies: LS-B15645.
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Products
Proteins
(10)
Type
Over-Expression Lysate
(4)
Recombinant
(6)
Target
Proenkephalin / PENK
(10)
Publications
No
(10)
Tag
6His, C-terminus
(2)
GST
(1)
His-T7
(1)
Myc-DDK (Flag)
(6)
Species
Human
(8)
Source
293T Cells
(2)
E. coli
(1)
HEK 293 Cells
(4)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(1)
Low Endotoxin Level
Low endotoxin level
(2)
Wheat Germ Extract
GST
55.11 kDa
2 µg/$439
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2kD
50 µg/$534
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$1,107
E. coli
His-T7
31.9 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
Human Proenkephalin / PENK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78231
293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
Human Proenkephalin / PENK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78232
293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2 kDa
10 µg/$317; 50 µg/$524
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