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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PRNP / PrP / Prion
prion protein
PRNP / PrP / Prion is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
| Gene Name: | prion protein |
| Synonyms: | PRNP, AltPrP, ASCR, CD230 antigen, CJD, KURU, Major prion protein, p27-30, Prion, Prion-related protein, PRIP, Prion protein (p27-30), PrP, PrP33-35C, BSE, CD230, Prion protein, PrP27-30, PrPc |
| Target Sequences: | NM_000311 NP_000302.1 P04156 |
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Products
Antibodies
(63)
ELISA Kits
(16)
Proteins
(9)
Type
Custom
(4)
Development Kit
(3)
Primary
(63)
Recombinant
(9)
Sandwich
(9)
Target
PRNP / PrP / Prion
(88)
Reactivity
Human
(44)
Mouse
(35)
Rat
(35)
Avian
(1)
Bovine
(9)
Cat
(5)
Chicken
(1)
Deer
(1)
Dog
(1)
Elk
(1)
Hamster
(6)
Pig
(1)
Sheep
(12)
Application
IHC
(25)
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(9)
WB
(49)
Flo
(3)
ELISA
(20)
IF
(1)
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(7)
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(1)
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(1)
Host
rabbit
(46)
mouse
(16)
goat
(1)
Product Group
DevKit DuoPlus
(3)
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(1)
PathPlus Neuro
(1)
Isotype
IgG
(18)
IgG1
(2)
IgG2a
(13)
IgG2a,k
(1)
Clonality
monoclonal mc
(16)
polyclonal pc
(47)
Clone
4H7
(1)
EM-20
(2)
ROS-1H9
(1)
ROS-BC6
(1)
ROS-BH1
(1)
T16-R
(1)
Format
96-Well Microplate
(1)
96-Well Strip Plate
(12)
Antibody Pair and Standard
(3)
APC
(2)
APC Conjugated
(3)
Biotin Conjugated
(7)
Cy3 Conjugated
(2)
Cy7 Conjugated
(2)
FITC Conjugated
(7)
HRP Conjugated
(7)
PE Conjugated
(4)
Unconjugated
(31)
Epitope
aa23-230
(16)
aa91-140
(4)
C-Terminus
(2)
aa140-145
(1)
aa142-148
(1)
aa143-159
(1)
aa143-230
(1)
aa143-aa154
(1)
aa144-154
(1)
aa144-160
(1)
aa162-170
(1)
aa217-229
(1)
aa79-97
(1)
Publications
No
(88)
Sample Type
Cell Culture Supernatants
(3)
Cell Lysates
(8)
Plasma
(5)
Serum
(5)
Tissue Homogenates
(10)
Tag
GST
(2)
His
(4)
His, N-Terminal
(2)
Human IgG Fc, C-terminus
(1)
Species
Human
(6)
Mouse
(1)
Rat
(2)
Source
E. coli
(5)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(2)
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
E. coli
His, N-Terminal
26.8 kDa
10 µg/$284; 50 µg/$462; 200 µg/$922; 1 mg/$2,042; 5 mg/$3,221; 2 mg/$2,231
PRNP / PrP / Prion Rabbit anti-Human Polyclonal (T16-R) Antibody
Mouse, Sheep, Bovine, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
Yeast
His
24.25 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Neuroscience
PRNP / PrP / Prion Mouse anti-Human Monoclonal (EM-20) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
PRNP / PrP / Prion Rabbit anti-Mouse Polyclonal (aa91-140) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
PRNP / PrP / Prion Goat anti-Human Polyclonal (aa79-97) Antibody
Human
IHC
Unconjugated
100 µl/$295
PRNP / PrP / Prion Rabbit anti-Human Polyclonal (aa23-230) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
PRNP / PrP / Prion Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human PRNP/Fc comprises 448 amino acids and has a predicted molecular mass of 49.7 kDa. The apparent molecular mass of the protein is approximately 57.4 kDa in SDS-PAGE under reducing conditions.
100 µg/$480
E. coli
His, N-Terminal
26.6 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
PRNP / PrP / Prion Mouse anti-Human Monoclonal (HRP) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (Biotin) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (FITC) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (APC) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,144
PRNP / PrP / Prion Mouse anti-Human Monoclonal (PE) Antibody
Hamster, Cat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,144
PRNP / PrP / Prion Rabbit anti-Mouse Polyclonal (aa143-159) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PRNP / PrP / Prion Mouse anti-Human Monoclonal Antibody
Mouse, Sheep, Bovine, Hamster, Deer, Elk, Human
ELISA, IHC, WB
Unconjugated
100 µl/$1,056
PRNP / PrP / Prion Mouse anti-Human Monoclonal (C-Terminus) (4H7) Antibody
Bovine, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$468
PRNP / PrP / Prion Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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product results
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