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PRLTS / PDGFRL encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
Gene Name: | platelet-derived growth factor receptor-like |
Synonyms: | PDGFRL, PDGRL, PRLTS, PDGFR-like protein |
Target Sequences: | NM_006207 NP_006198.1 Q15198 |
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