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PRKACB

protein kinase, cAMP-dependent, catalytic, beta

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Gene Name: protein kinase, cAMP-dependent, catalytic, beta
Family/Subfamily: Protein Kinase , cAMP
Synonyms: PRKACB, Cbeta, PKACB, PKA C-beta, PKA Cbeta
Target Sequences: NM_002731 NP_002722.1 P22694

Publications (1)

1
Protein Kinase A in Human Retina: Differential Localization of Cß, Ca, RIIa, and RIIß in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits. Jinae N Roa, Yuliang Ma, Zbigniew Mikulski, Qianlan Xu, Ronit Ilouz, Susan S Taylor, Dorota Skowronska-Krawczyk. Frontiers in molecular neuroscience. 2021 December;14:782041. [Full Text Article] [PubMed:34867193] [PMC:PMC8636463] Related Antibodies: LS-C191947.

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
PRKACB (8)
No (8)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
PRKACB Protein - 12.5% SDS-PAGE of human PRKACB stained with Coomassie Blue
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Wheat Germ Extract
GST
54.01 kDa
10 µg/$479; 25 µg/$670
PRKACB Protein - Purified recombinant protein PRKACB was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
40.4 kDa
20 µg/$1,107
PRKACB Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PRKACB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.4 kDa
20 µg/$150
PRKACB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
29.5 kDa
20 µg/$150
PRKACB Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
PRKACB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.4 kDa
100 µg/$494
PRKACB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
29.5 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).