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Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Gene Name: | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Family/Subfamily: | Protein Kinase Non Catalytic , AMPK/SNF1 |
Synonyms: | PRKAB2, AMPK beta-2 chain, AMPK beta 2, AMPK subunit beta-2 |
Target Sequences: | NM_005399 NP_005390.1 O43741 |
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