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PRF1 / Perforin
perforin 1 (pore forming protein)
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
| Gene Name: | perforin 1 (pore forming protein) |
| Synonyms: | PRF1, HPLH2, Perforin, p1, Perforin1, PFP, Cytolysin, FLH2, Perforin-1 |
| Target Sequences: | NM_005041 NP_005032.2 P14222 |
Publications (2)
1
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Wood SM, Meeths M, Chiang SC, Bechensteen AG, Boelens JJ, Heilmann C, Horiuchi H, Rosthj S, Rutynowska O, Winiarski J, Stow JL, Nordenskjld M, Henter JI, Ljunggren HG, Bryceson YT. Blood. 2009 114:4117-27.
[PubMed:19704116]
2
Anti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1-expressing preclinical ovarian cancer model. Mony JT, Zhang L, Ma T, Grabosch S, Tirodkar TS, Brozick J, Tseng G, Elishaev E, Edwards RP, Huang X, Vlad AM. Cancer immunology, immunotherapy : CII. 2015 September;64:1095-108. [Full Text Article]
[PubMed:25998800]
[PMC:PMC4545381]
Related Antibodies: LS-C18632.
☰ Filters
Products
Proteins
(16)
Type
Over-Expression Lysate
(4)
Recombinant
(12)
Target
PRF1 / Perforin
(16)
Publications
No
(16)
Tag
10His, N-terminus + Myc, C-terminus
(1)
6His, N-terminus
(3)
6His-SUMO, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(1)
His-GST, N-terminus
(2)
His-T7
(1)
MBP, N-terminus + 6His, C-terminus
(1)
Myc-DDK (Flag)
(4)
Species
Human
(10)
Mouse
(2)
Rat
(2)
Vibrio vulnificus
(1)
Source
293T Cells
(2)
Baculovirus
(1)
E. coli
(8)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(6)
Low Endotoxin Level
Low endotoxin level
(1)
E. coli
6His-SUMO, N-terminus
75.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
6His, N-terminus
59.2 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
His-GST, N-terminus
67.2 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
Wheat Germ Extract
GST
84.48 kDa
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
61.38 kDa
20 µg/$150
E. coli
His-GST, N-terminus
63.4 kDa
10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
E. coli
6His, N-terminus
62.9 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
293T Cells
Myc-DDK (Flag)
61.38 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
61.38 kDa
100 µg/$494
Baculovirus
MBP, N-terminus + 6His, C-terminus
103.2 kDa
100 µg/$1,164; 20 µg/$475; 1 mg/$2,187
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-T7
29.7 kDa
50 µg/$472; 10 µg/$286; 200 µg/$942; 100 µg/$752; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
HEK 293 Cells
Myc-DDK (Flag)
61.38 kDa
100 µg/$494
E. coli
10His, N-terminus + Myc, C-terminus
55.8 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
E. coli
308 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
33.99 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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