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PRF1 / Perforin

perforin 1 (pore forming protein)

Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

Gene Name: perforin 1 (pore forming protein)
Synonyms: PRF1, HPLH2, Perforin, p1, Perforin1, PFP, Cytolysin, FLH2, Perforin-1
Target Sequences: NM_005041 NP_005032.2 P14222

Publications (2)

1
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Wood SM, Meeths M, Chiang SC, Bechensteen AG, Boelens JJ, Heilmann C, Horiuchi H, Rosthj S, Rutynowska O, Winiarski J, Stow JL, Nordenskjld M, Henter JI, Ljunggren HG, Bryceson YT. Blood. 2009 114:4117-27. [PubMed:19704116]
2
Anti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1-expressing preclinical ovarian cancer model. Mony JT, Zhang L, Ma T, Grabosch S, Tirodkar TS, Brozick J, Tseng G, Elishaev E, Edwards RP, Huang X, Vlad AM. Cancer immunology, immunotherapy : CII. 2015 September;64:1095-108. [Full Text Article] [PubMed:25998800] [PMC:PMC4545381] Related Antibodies: LS-C18632.

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Products
ELISA Kits (26)
Competitive EIA (2)
Custom (2)
Sandwich (19)
Sandwich CLIA (3)
PRF1 / Perforin (26)
Human (7)
Mouse (7)
Rat (6)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (2)
96-Well Strip Plate (22)
No (26)
Cell Culture Supernatants (2)
Cell Lysates (3)
Plasma (19)
Serum (19)
Tissue Homogenates (8)
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$703
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$750
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
PRF1 / Perforin ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
PRF1 / Perforin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PRF1 / Perforin ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$784
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PRF1 / Perforin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PRF1 / Perforin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PRF1 / Perforin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PRF1 / Perforin ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).