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PRAME encodes a 509 amino acid antigen, lacking a signal sequence, and recognized on a human melanoma cell line by a T-lymphocyte clone. A significant level of PRAME mRNA is detected in normal testis as well as in many melanomas, non-small cell lung carcinomas, sarcomas, head and neck tumors and renal carcinomas. PRAME is expressed predominantly in acute leukemias carrying chromosomal abnormalities such as translocation t(8:21), which fuses the AML1 and ETO genes. PRAME expression shares several characteristics with the expression patterns of MAGE, BAGE, and GAGE gene families, all of which are expressed in tumors. PRAME is expressed in a higher proportion of samples than genes of the MAGE, BAGE, and GAGE families, and of these four groups, only PRAME is expressed by acute myeloid leukemias.
Gene Name: | preferentially expressed antigen in melanoma |
Synonyms: | PRAME, Cancer/testis antigen 130, CT130, MAPE, Opa-interacting protein 4, Opa-interacting protein OIP4, OIP-4, OIP4 |
Target Sequences: | NM_006115 NP_006106.1 P78395 |
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