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PR / Progesterone Receptor

progesterone receptor

The progesterone receptor, a NR3 Steroid Receptor, is induced in granulosa cells of preovulatory follicles in response to surges in luteinizing hormone. It is essential for ovulation and egg implantation. A decrease in expression of endometrial progesterone receptor results in infertility in women. This receptor mediates the progesterone-induced transcription of proteases including ADAMTS1 and cathepsin L. In breast cancer, progesterone receptors are associated with hormone dependence and prolonged survival. At least two alternatively spliced isoforms have been identified in human: hPR-A (94 kD) is 164 aa shorter than hPR-B (114 kD). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. hPR-A and hPR-B have been shown to regulate different sets of genes in human breast cancer cells. Some of these PR-regulated genes are implicated in breast cancer.

Gene Name: progesterone receptor
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: PGR, NR3C3, PR, Progesterone receptor
Target Sequences: NM_000926 AAS00096.1 P06401

Publications (6)

1
Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. The American journal of pathology. 2010 176:1639-47. (IHC) [PubMed:20150438] [PMC:PMC2843456]
2
Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model. Ezoe K, Murata N, Yabuuchi A, Kobayashi T, Kato K. Scientific reports. 2019 August;9:12519. [Full Text Article] [PubMed:31467307] [PMC:PMC6715633]
3
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701]
4
Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice. Alisa A Suen, Wendy N Jefferson, Carmen J Williams, Charles E Wood. Toxicologic pathology. 2018 July;46:574-596. [Full Text Article] [PubMed:29895210] [PMC:PMC6027618]
5
Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies. Daven N Jackson-Humbles, John Curtis Seely, Ronald A Herbert, David E Malarkey, Barry S McIntyre, Paul M Foster, Darlene Dixon. Toxicologic pathology. 2018 Jun;46:421-430. [Full Text Article] [PubMed:29706125] [PMC:PMC5999558]
6
Establishment of two basal-like breast cancer cell lines with extremely low tumorigenicity from Taiwanese premenopausal women. Wen-Ling Kuo, Shir-Hwa Ueng, Chun-Hsing Wu, Li-Yu Lee, Yun-Shien Lee, Ming-Chin Yu, Shin-Cheh Chen, Chi-Chang Yu, Chi-Neu Tsai. Human cell. 2018 Apr;31:154-166. [Full Text Article] [PubMed:29484537] [PMC:PMC5852199] Related Antibodies: LS-C133381.
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ELISA Kits (25)
Cell-Based (1)
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DNA Binding (1)
Sandwich (13)
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PR / Progesterone Receptor (25)
Human (11)
Mouse (4)
Rat (6)
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Dog (1)
Guinea pig (1)
Monkey (1)
Rabbit (1)
12 x 8-Well Microstrips (4)
96-Well Microplate (7)
96-Well Strip Plate (14)
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Cell Lysates (2)
Nuclear Lysates (1)
Plasma (13)
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PR / Progesterone Receptor ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
PR / Progesterone Receptor ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PR / Progesterone Receptor ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
PR / Progesterone Receptor ELISA Kit
Select
DNA Binding
12 x 8-Well Microstrips
Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$694
PR / Progesterone Receptor ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
PR / Progesterone Receptor ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
PR / Progesterone Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PR / Progesterone Receptor ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
PR / Progesterone Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
PR / Progesterone Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PR / Progesterone Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PR / Progesterone Receptor ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
PR / Progesterone Receptor ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PR / Progesterone Receptor ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).