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PPY / Pancreatic Polypeptide

pancreatic polypeptide

PPY / Pancreatic Polypeptide belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.

Gene Name: pancreatic polypeptide
Family/Subfamily: Pancreatic hormone , not assigned-Pancreatic hormone
Synonyms: PPY, Obinepitide, Pancreatic polypeptide Y, Pancreatic prohormone, PP, Pancreatic polypeptide, Pancreatic hormone
Target Sequences: NM_002722 NP_002713.1 P01298

Publications (4)

1
Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic ? cells. Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani. PloS one. 2022 August;17:e0269958. [Full Text Article] [PubMed:35976945] [PMC:PMC9385059]
2
Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Chen Y, Hong F, Chen H, Fan RF, Zhang XL, Zhang Y, Zhu JX. Cell and tissue research. 2014 Sep;357:597-606. [Full Text Article] [PubMed:24825414] Related Antibodies: LS-B5911.
3
New perspectives of vesicular monoamine transporter 2 chemical characteristics in mammals and its constant expression in type 1 diabetes rat models. Hong F, Liu L, Fan RF, Chen Y, Chen H, Zheng RP, Zhang Y, Gao Y, Zhu JX. Translational research : the journal of laboratory and clinical medicine. 2014 Feb;163:171-82. [Full Text Article] [PubMed:24161354] Related Antibodies: LS-B5911.
4
Differential expression and localization of neuropeptide Y peptide in pancreatic islet of diabetic and high fat fed rats. Ruipan Z, Xiangzhi M, Li L, Ying Z, Mingliang Q, Peng J, Jingwei L, Zijun Z, Yan G. Peptides. 2014 Apr;54:33-8. [Full Text Article] [PubMed:24462552] Related Antibodies: LS-B5911.
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Proteins (6)
Recombinant (6)
PPY / Pancreatic Polypeptide (6)
No (6)
6His, C-terminus (2)
GST (1)
His-GST (2)
Myc-DDK (Flag) (1)
Human (5)
Mouse (1)
E. coli (2)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
PPY / Pancreatic Polypeptide Protein - Recombinant Pancreatic Polypeptide By SDS-PAGE
Select
E. coli
His-GST
39.0 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
PPY / Pancreatic Polypeptide Protein - Recombinant Pancreatic Polypeptide By SDS-PAGE
Select
E. coli
His-GST
39.8 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
7.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
PPY / Pancreatic Polypeptide Protein - 12.5% SDS-PAGE of human PPY stained with Coomassie Blue
Select
Wheat Germ Extract
GST
36.19 kDa
10 µg/$479; 25 µg/$670
PPY / Pancreatic Polypeptide Protein - Purified recombinant protein PPY was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
7.5 kDa
20 µg/$1,107
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
7.8 kDa
10 µg/$317; 50 µg/$524
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).