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Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
Gene Name: | protein phosphatase 6, catalytic subunit |
Family/Subfamily: | Protein Phosphatase , Protein Phosphatase - Serine/Threonine other |
Synonyms: | PPP6C, PP6, PP6C, PPP6, Protein phosphatase 6 |
Target Sequences: | NM_002721 NP_002712.1 O00743 |
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