PPP5C

protein phosphatase 5, catalytic subunit

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PPP5C (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Purified (1)

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Human PPP5C Protein (Recombinant GST) (Full Length) - LS-G29871

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.63 kDa

Price:

10 µg/$479; 25 µg/$670

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PPP5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115430

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.7 kDa

Price:

100 µg/$494

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Human PPP5C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78746

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.7 kDa

Price:

20 µg/$150

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