PPP4C

protein phosphatase 4, catalytic subunit

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

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Products

Antibodies (38)

Type

Primary (38)

Target

PPP4C (38)

Reactivity

Human (38)

Mouse (17)

Rat (12)

Bat (4)

Bovine (6)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (4)

Horse (4)

Monkey (4)

Orangutan (3)

Pig (3)

Rabbit (4)

Xenopus (4)

Zebrafish (4)

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Application

IHC (26)

IHC-P (6)

WB (37)

ELISA (10)

ICC (4)

IF (6)

IP (5)

Peptide-ELISA (2)

Host

rabbit (25)

mouse (11)

goat (1)

sheep (1)

Product Group

IHCPlus (3)

Isotype

IgG (17)

IgG2a (5)

IgG2a,k (1)

IgG2b (3)

Clonality

monoclonal mc (11)

polyclonal pc (27)

Clone

1E8 (1)

OTI2E4 (2)

OTI2H7 (2)

OTI2H8 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (3)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Preservative Free (1)

Unconjugated (30)

Epitope

aa160-189 (7)

C-Terminus (4)

aa1-50 (2)

aa294-307 (2)

Internal (1)

aa1-307 (1)

aa290-301 (1)

Publications

No (38)

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IHC-plus™ PPP4C Antibody (aa290-301) LS-B3614

(4.0) Rating

Antibody:

PPP4C Goat anti-Human Polyclonal (aa290-301) Antibody

Reactivity:

Xenopus, Zebrafish, Horse, Rat, Hamster, Rabbit, Mouse, Dog, Bovine, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ PPP4C Antibody (aa294-307) LS-B752

(4.0) Rating

Antibody:

PPP4C Rabbit anti-Bovine Polyclonal (aa294-307) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ PPP4C Antibody LS-B10985

(4.0) Rating

Antibody:

PPP4C Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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PPP4C Antibody LS-C331901

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PPP4C Antibody LS-C482349

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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PPP4C Antibody LS-C393486

Antibody:

PPP4C Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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PPP4C Antibody LS-C769823

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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PPP4C Antibody (aa1-50) LS-C287684

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PPP4C Antibody (clone OTI2H8) LS-C795334

Antibody:

PPP4C Mouse anti-Human Monoclonal (OTI2H8) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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PPP4C Antibody (clone OTI2H8, Carrier-free) LS-C799688

Antibody:

PPP4C Mouse anti-Human Monoclonal (Carrier-free) (OTI2H8) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PPP4C Antibody (clone OTI2E4) LS-C795337

Antibody:

PPP4C Mouse anti-Human Monoclonal (OTI2E4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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PPP4C Antibody (clone OTI2E4, Carrier-free) LS-C792386

Antibody:

PPP4C Mouse anti-Human Monoclonal (Carrier-free) (OTI2E4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PPP4C Antibody (clone OTI2H7) LS-C795338

Antibody:

PPP4C Mouse anti-Human Monoclonal (OTI2H7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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PPP4C Antibody (clone OTI2H7, Carrier-free) LS-C792389

Antibody:

PPP4C Mouse anti-Human Monoclonal (Carrier-free) (OTI2H7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

PPP4C Antibody LS-C748577

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PPP4C Antibody (aa160-189) LS-C324250

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PPP4C Antibody (aa160-189, Biotin) LS-C266978

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PPP4C Antibody (aa160-189, FITC) LS-C266979

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PPP4C Antibody (aa160-189, APC) LS-C266977

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PPP4C Antibody (aa160-189, PE) LS-C266982

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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PPP4C Antibody (aa160-189, Azide-free, HRP) LS-C266981

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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PPP4C Antibody LS-C751866

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

PPP4C Antibody LS-C769822

Antibody:

PPP4C Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

PPP4C Antibody LS-C813080

Antibody:

PPP4C Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

PPP4C Antibody (aa160-189) LS-C162094

Antibody:

PPP4C Rabbit anti-Human Polyclonal (aa160-189) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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