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PPP2R3A / PR130
protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3A / PR130 is one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. The B' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B'. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | protein phosphatase 2, regulatory subunit B'', alpha |
| Synonyms: | PPP2R3A, PR130, PR72, PPP2R3, PP2A, subunit B, R3 isoform |
| Target Sequences: | NM_002718 NP_002709.2 Q06190 |
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