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PPP2R1A is a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
Gene Name: | protein phosphatase 2, regulatory subunit A, alpha |
Synonyms: | PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A |
Target Sequences: | NM_014225 NP_055040.2 P30153 |
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