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Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
Gene Name: | protein phosphatase 1, regulatory subunit 8 |
Synonyms: | PPP1R8, ARD-1, ARD1, Activator of RNA decay, NIPP-1, NIPP1, Nuclear subunit of PP-1, PRO2047, RNase E |
Target Sequences: | NM_002713 NP_002704.1 Q12972 |
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