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Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Gene Name: | protein phosphatase 1, regulatory (inhibitor) subunit 1A |
Synonyms: | PPP1R1A, I-1, I1, Inhibitor-1, IPP1, IPP-1 |
Target Sequences: | NM_006741 NP_006732.3 Q13522 |
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