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PPP1R17 / C7orf16 is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | protein phosphatase 1, regulatory subunit 17 |
Synonyms: | PPP1R17, G-substrate, GSBS, C7orf16 |
Target Sequences: | NM_006658 NP_006649.2 O96001 |
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